Mg2+ efflux is accomplished by an amiloride-sensitive Na+/Mg2+ antiport.


Mg2+ efflux from Mg2+-preloaded chicken erythrocytes is caused by an electroneutral Na+/Mg2+ antiport. It depends specifically on extracellular Na+, according to Michaelis-Menten kinetics (Km = 25 mM), and is reversibly noncompetitively inhibited by amiloride (Ki = 0.59 mM). In contrast to Na+/H+ antiport, Li+, Ca2+ and N-ethylmaleimide do not interfere with Na+/Mg2+ antiport. The Na+/Mg2+ antiport is driven by the intracellular/extracellular Mg2+ gradient.


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@article{Gnther1985Mg2EI, title={Mg2+ efflux is accomplished by an amiloride-sensitive Na+/Mg2+ antiport.}, author={Theodor G{\"{u}nther and Juergen Vormann}, journal={Biochemical and biophysical research communications}, year={1985}, volume={130 2}, pages={540-5} }