Mg2+ ions: do they bind to nucleobase nitrogens?

@article{Leonarski2017Mg2ID,
  title={Mg2+ ions: do they bind to nucleobase nitrogens?},
  author={F. Leonarski and Luigi D’Ascenzo and P. Auffinger},
  journal={Nucleic Acids Research},
  year={2017},
  volume={45},
  pages={987 - 1004}
}
Given the many roles proposed for Mg2+ in nucleic acids, it is essential to accurately determine their binding modes. Here, we surveyed the PDB to classify Mg2+ inner-sphere binding patterns to nucleobase imine N1/N3/N7 atoms. Among those, purine N7 atoms are considered to be the best nucleobase binding sites for divalent metals. Further, Mg2+ coordination to N7 has been implied in several ribozyme catalytic mechanisms. We report that Mg2+ assigned near imine nitrogens derive mostly from poor… Expand
Deflating the RNA Mg2+ bubble. Stereochemistry to the rescue!
Consequences of Mg2+ binding on the geometry and stability of RNA base pairs.
Hofmeister Series for Metal-Cation–RNA Interactions: The Interplay of Binding Affinity and Exchange Kinetics
Deflating the RNA Mg2+ bubble. Stereochemistry to the rescue!
Theory and simulations for RNA folding in mixtures of monovalent and divalent cations
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 209 REFERENCES
Metal ion-N7 coordination in a ribozyme branch domain by NMR.
Symmetric K+ and Mg2+ ion-binding sites in the 5S rRNA loop E inferred from molecular dynamics simulations.
Metal ion binding to RNA.
A crystallographic study of the binding of 13 metal ions to two related RNA duplexes.
...
1
2
3
4
5
...