Mg2+ -dependent ATP occlusion at the first nucleotide-binding domain (NBD1) of CFTR does not require the second (NBD2).

Abstract

ATP binding to the first and second NBDs (nucleotide-binding domains) of CFTR (cystic fibrosis transmembrane conductance regulator) are bivalent-cation-independent and -dependent steps respectively [Aleksandrov, Aleksandrov, Chang and Riordan (2002) J. Biol. Chem. 277, 15419-15425]. Subsequent to the initial binding, Mg(2+) drives rapid hydrolysis at the… (More)
DOI: 10.1042/BJ20081068

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@article{Aleksandrov2008Mg2A, title={Mg2+ -dependent ATP occlusion at the first nucleotide-binding domain (NBD1) of CFTR does not require the second (NBD2).}, author={Luba Aleksandrov and Andrei Aleksandrov and John R. Riordan}, journal={The Biochemical journal}, year={2008}, volume={416 1}, pages={129-36} }