Mg(2+)-sensitive non-capacitative basolateral Ca(2+) entry secondary to cell swelling in the polarized renal A6 epithelium.

@article{Jans2002Mg2sensitiveNB,
  title={Mg(2+)-sensitive non-capacitative basolateral Ca(2+) entry secondary to cell swelling in the polarized renal A6 epithelium.},
  author={Danny Jans and Paul De Weer and Sangly P Srinivas and Els Larivi{\`e}re and Jeannine Simaels and Willy van Driessche},
  journal={The Journal of physiology},
  year={2002},
  volume={541 Pt 1},
  pages={91-101}
}
Polarized renal A6 epithelia respond to hyposmotic shock with an increase in transepithelial capacitance (C(T)) that is inhibited by extracellular Mg(2+). Elevation of free cytosolic [Ca(2+)] ([Ca(2+)](i)) is known to increase C(T). Therefore, we examined [Ca(2+)](i) dynamics and their sensitivity to extracellular Mg(2+) during hyposmotic conditions. Fura-2-loaded A6 monolayers, cultured on permeable supports were subjected to a sudden reduction in osmolality at both the basolateral and apical… CONTINUE READING

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