Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

@article{Nguyen2014Mfsd2aIA,
  title={Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid},
  author={Long N. Nguyen and Dongliang Ma and Guanghou Shui and Peiyan Wong and Amaury Cazenave-Gassiot and Xiaodong Zhang and Markus R. Wenk and Eyleen L. K. Goh and David L. Silver},
  journal={Nature},
  year={2014},
  volume={509},
  pages={503-506}
}
Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is essential for normal brain growth and cognitive function. Consistent with its importance in the brain, DHA is highly enriched in brain phospholipids. Despite being an abundant fatty acid in brain phospholipids, DHA cannot be de novo synthesized in brain and must be imported across the blood–brain barrier, but mechanisms for DHA uptake in brain have remained enigmatic. Here we identify a member of the major facilitator superfamily… 

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
It is discovered that a member of the long-chain acyl-CoA synthetase family, Acsl6, is required for the enrichment of DHA in the brain by generating an AcSl6-deficient mouse (Acsl6−/−).

Mfsd2a: A Physiologically Important Lysolipid Transporter in the Brain and Eye.

TLDR
Beyond its role in brain development, LPC-DHA uptake in the brain and eye negatively regulates de novo lipogenesis and the proposed transport mechanism of Mfsd2a is focused on.

Specific uptake of DHA by the brain from a structured phospholipid, AceDoPC®

TLDR
Findings suggested that DHA is better incorporated into the brain when esterified at the sn- 2 position of a lysophosphatidylcholine (LysoPC-DHA).

Fatty Acid-Binding Protein 5 Facilitates the Blood-Brain Barrier Transport of Docosahexaenoic Acid.

TLDR
It is demonstrated that FABP5 binds to DHA and is involved in the brain endothelial cell uptake and subsequent BBB transport of DHA, confirming the importance of this cytoplasmic carrier protein in the CNS exposure of this PUFA essential for neuronal function.
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