Mexiletine for thalamic pain syndrome.

  title={Mexiletine for thalamic pain syndrome.},
  author={G I Awerbuch and Reuven Sandyk},
  journal={The International journal of neuroscience},
  volume={55 2-4},
The thalamic pain syndrome, a rare sequelae of cerebrovascular event, is a severe and disabling form of central pain which treatment remains a major clinical problem. We present our results of a preliminary open label study using mexiletine, an orally active antiarrhythmic agent, in the management of thalamic pain in 9 patients. Using a dose of 10 mg/kg/day over a 4-week period, mexiletine produced improvement in pain in 8 of the 9 patients. Mexiletine was generally well tolerated with only two… CONTINUE READING