Mexiletine: Pharmacology and therapeutic use

@article{Manolis1990MexiletinePA,
  title={Mexiletine: Pharmacology and therapeutic use},
  author={A. Manolis and T. Deering and J. Cameron and N. Markestes},
  journal={Clinical Cardiology},
  year={1990},
  volume={13}
}
Mexiletine is a Class IB antiarrhythmic which has basic and clinical electrophysiologic properties similar to lidocaine. Like other Class I antiarrhythmic agents, mexiletine blocks the rapid inward sodium current responsible for phase 0 of the action potential. It has been noted in the clinical electrophysiology laboratory to have minimal effect on sinus node function and AV nodal and His‐Purkinje system conduction. Pharmacokinetic studies have shown that oral absorption is rapid with… Expand
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Pharmacology and Clinical Use of Mexiletine
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