Mevalonate metabolism governs cancer immune surveillance

  title={Mevalonate metabolism governs cancer immune surveillance},
  author={Georg Gruenbacher and Martin Thurnher},
The metabolic reprogramming that drives immunity engages the mevalonate pathway for cholesterol biosynthesis and protein prenylation. The importance of tight regulation of this metabolic route is reflected by the fact that too low activity impairs cellular function and survival, whereas hyperactivity can lead to malignant transformation. Here, we first address how mevalonate metabolism drives immunity and then highlight ways of the immune system to respond to both, limited and uncontrolled flux… CONTINUE READING
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