Mevalonate deprivation mediates the impact of lovastatin on the differentiation of murine 3T3-F442A preadipocytes.

@article{Elfakhani2014MevalonateDM,
  title={Mevalonate deprivation mediates the impact of lovastatin on the differentiation of murine 3T3-F442A preadipocytes.},
  author={Manal Elfakhani and Sheida Torabi and Deema Hussein and Nathaniel Mills and Guido F. Verbeck and Huanbiao Mo},
  journal={Experimental biology and medicine},
  year={2014},
  volume={239 3},
  pages={293-301}
}
The statins competitively inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase activity and consequently the synthesis of mevalonate. The use of statins is associated with insulin resistance, presumably due to the impaired differentiation and diminished glucose utilization of adipocytes. We hypothesize that mevalonate is essential to adipocyte differentiation and adipogenic gene expression. Adipo-Red assay and Oil Red O staining showed that an eight-day incubation with 0-2.5 µmol/L… CONTINUE READING

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