Mevalonate Pathway Regulates Cell Size Homeostasis and Proteostasis through Autophagy

@inproceedings{Miettinen2015MevalonatePR,
  title={Mevalonate Pathway Regulates Cell Size Homeostasis and Proteostasis through Autophagy},
  author={Teemu P. Miettinen and Mikael Bj{\"o}rklund},
  booktitle={Cell reports},
  year={2015}
}
Balance between cell growth and proliferation determines cell size homeostasis, but little is known about how metabolic pathways are involved in the maintenance of this balance. Here, we perform a screen with a library of clinically used drug molecules for their effects on cell size. We find that statins, inhibitors of the mevalonate pathway, reduce cell… CONTINUE READING