Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis

@article{Lin2017Mettl3Mettl14mediatedMN,
  title={Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis},
  author={Zhen Lin and Phillip J Hsu and Xudong Xing and Jianhuo Fang and Zhike Lu and Qin Zou and Ke-Jia Zhang and Xiao Zhang and Yuchuan Zhou and Teng Zhang and You Cheng Zhang and Wanlu Song and Guifang Jia and Xuerui Yang and Chuan He and Ming-Han Tong},
  journal={Cell Research},
  year={2017},
  volume={27},
  pages={1216-1230}
}
Spermatogenesis is a differentiation process during which diploid spermatogonial stem cells (SSCs) produce haploid spermatozoa. This highly specialized process is precisely controlled at the transcriptional, posttranscriptional, and translational levels. Here we report that N6-methyladenosine (m6A), an epitranscriptomic mark regulating gene expression, plays essential roles during spermatogenesis. We present comprehensive m6A mRNA methylomes of mouse spermatogenic cells from five developmental… CONTINUE READING
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