Metronomic therapy with cyclophosphamide induces rat lymphoma and sarcoma regression, and is devoid of toxicity.

@article{Rozados2004MetronomicTW,
  title={Metronomic therapy with cyclophosphamide induces rat lymphoma and sarcoma regression, and is devoid of toxicity.},
  author={V R Rozados and Andrea M S{\'a}nchez and Silvia I. Gervasoni and Hector H. Berra and Pablo Matar and O Graciela Scharovsky},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2004},
  volume={15 10},
  pages={1543-50}
}
BACKGROUND Our aim was to investigate the clinical efficacy and toxicity of metronomic administration of low-dose cyclophosphamide (Cy) in lymphoma and sarcoma rat tumour models. METHODS Adult inbred rats were challenged with lymphoma TACB and sarcoma E100 s.c. on day 0. Animals were divided into two groups: group I, control, injected with saline three times a week; and group II, treated with Cy 10 mg/kg three times a week, from day 10 until the tumour was non-palpable, or 5 mg/kg three times… CONTINUE READING
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