Metronomic chemotherapy: new rationale for new directions

  title={Metronomic chemotherapy: new rationale for new directions},
  author={Eddy Pasquier and Maria Kavallaris and Nicolas Andr{\'e}},
  journal={Nature Reviews Clinical Oncology},
Tumor angiogenesis is recognized as a major therapeutic target in the fight against cancer. The key involvement of angiogenesis in tumor growth and metastasis has started to redefine chemotherapy and new protocols have emerged. Metronomic chemotherapy, which is intended to prevent tumor angiogenesis, is based on more frequent and low-dose drug administrations compared with conventional chemotherapy. The potential of metronomic chemotherapy was revealed in animal models a decade ago and the… CONTINUE READING
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