Metronidazole uptake by sensitive and resistant isolates of Helicobacter pylori.

  title={Metronidazole uptake by sensitive and resistant isolates of Helicobacter pylori.},
  author={Sara Lacey and Steven F. Moss and Graham W Taylor},
  journal={The Journal of antimicrobial chemotherapy},
  volume={32 3},
The development of metronidazole resistance in Helicobacter pylori has become an important factor in the clinical use of this drug in the treatment of gastritis and peptic ulcers. The mechanism for the development of resistance is not known but may involve factors which influence metronidazole uptake and metabolism. In this study, a simple and reliable HPLC assay for metronidazole was developed and the uptake of the drug from broth cultures of both resistant and sensitive strains of H. pylori… CONTINUE READING

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