Metronidazole reduces the expression of cytochrome P450 enzymes in HepaRG cells and cryopreserved human hepatocytes

@article{Kudo2015MetronidazoleRT,
  title={Metronidazole reduces the expression of cytochrome P450 enzymes in HepaRG cells and cryopreserved human hepatocytes},
  author={Toshiyuki Kudo and Y. Endo and Rina Taguchi and Masami Yatsu and Kiyomi Ito},
  journal={Xenobiotica},
  year={2015},
  volume={45},
  pages={413 - 419}
}
Abstract 1. Blood levels of S-warfarin have been reported to be increased by concomitant administration of metronidazole (MTZ), an antiprotozoal imidazole derivative. 2. To elucidate the mechanism of this interaction and to identify other possible drug-drug interactions, we conducted an in vitro study with the human hepatoma HepaRG cells and cryopreserved human hepatocytes on the ability of MTZ to reduce the expression of cytochrome P450 (CYP) as well as nuclear receptors that regulate the… 
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Xenobiotic Metabolising Enzymes: Impact on Pathologic Conditions, Drug Interactions and Drug Design.

Study of drug metabolism is of major importance for the development of drugs and provides insight into the control of human health, and some of the previous research results are presented, which may assist in the elucidation of xenobiotic metabolism and in thedevelopment of more efficient drugs.

The different metabolism of morusin in various species and its potent inhibition against UDP-glucuronosyltransferase (UGT) and cytochrome p450 (CYP450) enzymes

This study provided vital information to understand the inhibitory potential and metabolic behavior of morusin among various species and exhibited significant species differences.

Revisiting CYP2C9-Mediated drug-drug Interactions: A Review

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APPLICATION OF MODIFIED MICHAELIS – MENTEN EQUATIONS FOR DETERMINATION OF ENZYME INDUCING AND INHIBITING DRUGS

Pharmacokinetic-pharmacodynamic translation can be optimally achieved by incorporating newly derived Michaelis-Menten equations into pharmacokinetic parameters for clinical efficacy and safety of therapeutics.

Application of modified Michaelis – Menten equations for determination of enzyme inducing and inhibiting drugs

  • S. Saganuwan
  • Biology, Chemistry
    BMC pharmacology & toxicology
  • 2021
Pharmacokinetic-pharmacodynamic translation can be optimally achieved by incorporating, newly modified Michaelis-Menten equations into pharmacokinetic formulas for clinical efficacy and safety of the enzyme inducing and inhibiting therapeutic agents used in laboratory and clinical settings.

Optimized HepaRG is a suitable cell source to generate the human liver chimeric mouse model for the chronic hepatitis B virus infection

The experimental results showed that the liver chimerism of the mice was adequate to support chronic HBV infection for 24 weeks and to evaluate antivirals, and overall, HepaRG-FRGS mice provide a novel human liver chimeric mouse model to study chronicHBV infection and evaluate anti-HBV drugs.

Review of Warfarin; A Cytochrome P450 Metabolizing Drug, in Clinical Practice

To obtain a reasonable level of stability between the required antithrombotic treatment and the risk of bleeding, an anal- ysis of the literature revealed that the prothrombin time in terms of the international normalized ratio (INR) was found for each individual.

Degradation of Metronidazole Antibiotic Using a Novel Synthesised Magnetic Nanocomposite in Heterogeneous Fenton-like Catalytic Process

Antibiotics are organic pollutants that are introduced into surface water and underground water sources due to urban and industrial effluents. Due to their high stability, they do not only disrupt…

Drug-drug interactions with metronidazole and itraconazole in patients using acenocoumarol

Co-trimoxazole, metronidazoles, and itraconazole increase the risk of overanticoagulation in patients using acenocoumarol, and these combinations should be avoided if possible or otherwise acenOCou marol doses should be reduced and INR measured more frequently.

Drug-drug interactions with metronidazole and itraconazole in patients using acenocoumarol

Purpose Various population-based cohort studies have shown that antimicrobial agents increase the risk of overanticoagulation in patients using coumarins. In this study, we assessed this association…

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