Metronidazole reduces the expression of cytochrome P450 enzymes in HepaRG cells and cryopreserved human hepatocytes

@article{Kudo2015MetronidazoleRT,
  title={Metronidazole reduces the expression of cytochrome P450 enzymes in HepaRG cells and cryopreserved human hepatocytes},
  author={Toshiyuki Kudo and Y. Endo and Rina Taguchi and Masami Yatsu and Kiyomi Ito},
  journal={Xenobiotica},
  year={2015},
  volume={45},
  pages={413 - 419}
}
Abstract 1. Blood levels of S-warfarin have been reported to be increased by concomitant administration of metronidazole (MTZ), an antiprotozoal imidazole derivative. 2. To elucidate the mechanism of this interaction and to identify other possible drug-drug interactions, we conducted an in vitro study with the human hepatoma HepaRG cells and cryopreserved human hepatocytes on the ability of MTZ to reduce the expression of cytochrome P450 (CYP) as well as nuclear receptors that regulate the… 

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