Metronidazole population pharmacokinetics in preterm neonates using dried blood-spot sampling.

@article{Suyagh2011MetronidazolePP,
  title={Metronidazole population pharmacokinetics in preterm neonates using dried blood-spot sampling.},
  author={Maysa Faisal Suyagh and Paul S. Collier and Jeffrey Stuart Millership and Godwill Iheagwaram and Muriel Millar and Henry L. Halliday and James C McElnay},
  journal={Pediatrics},
  year={2011},
  volume={127 2},
  pages={e367-74}
}
OBJECTIVES To characterize the population pharmacokinetics of metronidazole in preterm neonates. PATIENTS AND METHODS Data were collected prospectively from 32 preterm neonates who received intravenous metronidazole for the treatment of or prophylaxis against necrotizing enterocolitis. Dried blood spots (n = 203) on filter paper were analyzed by high-performance liquid chromatography, and the data were subjected to pharmacokinetic analysis performed by using nonlinear mixed-effect modeling… CONTINUE READING

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