Metronidazole induces programmed cell death in the protozoan parasite Blastocystis hominis.

@article{Nasirudeen2004MetronidazoleIP,
  title={Metronidazole induces programmed cell death in the protozoan parasite Blastocystis hominis.},
  author={A. M. A. Nasirudeen and Yap Eu Hian and Mulkit Singh and Kevin S. W. Tan},
  journal={Microbiology},
  year={2004},
  volume={150 Pt 1},
  pages={33-43}
}
Previous studies by the authors have shown that the protozoan parasite Blastocystis hominis succumbed to a cytotoxic monoclonal antibody with a number of cellular and biochemical features characteristic of apoptosis in higher eukaryotes. The present study reports that apoptosis-like features are also observed in growing cultures of axenic B. hominis upon exposure to metronidazole, a drug commonly used for the treatment of blastocystosis. Upon treatment with the drug, B. hominis cells displayed… CONTINUE READING

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