Metronidazole concentrations in plasma, saliva and periodontal pockets in patients with periodontitis.

@article{Phkla2005MetronidazoleCI,
  title={Metronidazole concentrations in plasma, saliva and periodontal pockets in patients with periodontitis.},
  author={Ene-Renate P{\"a}hkla and Taive Koppel and Mare Saag and Rein P{\"a}hkla},
  journal={Journal of clinical periodontology},
  year={2005},
  volume={32 2},
  pages={163-6}
}
OBJECTIVES Metronidazole is widely used antibacterial compound in the treatment of some types of periodontal disease. Pharmacokinetics of metronidazole in plasma has been well-described but few data exist about penetration of the drug to the gingival crevice fluid. The aim of the present study was to compare the concentrations of metronidazole in plasma, saliva and gingival crevice fluid in patients with periodontitis after multiple administration. MATERIALS AND METHODS Eleven patients with… CONTINUE READING