Metoprolol and debrisoquin metabolism in Nigerians: lack of evidence for polymorphic oxidation.

@article{Iyun1986MetoprololAD,
  title={Metoprolol and debrisoquin metabolism in Nigerians: lack of evidence for polymorphic oxidation.},
  author={A O Iyun and Martin S. Lennard and Geoffrey T. Tucker and Henri Woods},
  journal={Clinical pharmacology and therapeutics},
  year={1986},
  volume={40 4},
  pages={387-94}
}
The role of genetic polymorphism in the oxidative metabolism of metoprolol and debrisoquin was investigated in a population of 138 unrelated Nigerians. The debrisoquin/4-hydroxydebrisoquin 0-8 hour urinary ratio (D/HD) correlated significantly with the metoprolol/alpha-hydroxymetoprolol 0-8 hour urinary ratio (M/HM) (rs = 0.54; P less than 0.001), the metoprolol/H117-04 [4-(2-hydroxy-3-isopropylaminopropoxy)-phenylacetic acid] 0-8 hour urinary ratio (M/H117-04) (rs = 0.42; P less than 0.001… CONTINUE READING

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