Metoprine induced behavioral modifications and brain regional histamine increase in WAG/Rij and Wistar rats.

@article{Samotaeva2012MetoprineIB,
  title={Metoprine induced behavioral modifications and brain regional histamine increase in WAG/Rij and Wistar rats.},
  author={Irina Samotaeva and Lidiya M Birioukova and Inna S Midzyanovskaya and G. D. Kuznetsova and Ara S. Bazyan and Leena M Tuomisto},
  journal={Epilepsy research},
  year={2012},
  volume={101 1-2},
  pages={148-56}
}
The effects of metoprine, an inhibitor of histamine N-methyltransferase, on open field activity and brain regional histamine (HA) content were examined in rats with mixed, absence and audiogenic, epilepsy (WAG/Rij-AGS), rats with audiogenic epilepsy (Wistar-AGS) and in non-epileptic control rats (Wistar-nAGS). HA content was increased by metoprine (20mg/kg, i.p.) in the cortex, striatum, thalamus, hypothalamus and hippocampus of the rats from all three tested groups. However, WAG/Rij rats… CONTINUE READING