Metolazone therapy of active calcium nephrolithiasis

@article{Cunningham1982MetolazoneTO,
  title={Metolazone therapy of active calcium nephrolithiasis},
  author={E. Cunningham and F. H. Oliveros and L. Nascimento},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1982},
  volume={32}
}
Metolazone, a nonthiazide diuretic with the hypocalciuric effect of the thiazides, was evaluated in patients with idiopathic calcium nephrolithiasis. During the mean 3‐yr treatment period, there was a 77% decrease in stone incidence in 38 male patients (from 2.10 to 0.49 stones/patient/year). Urine calcium decreased 51% (from 231 ± 19 to 114 ± 7 mg/24 hr after 13 mo therapy). The treatment response was the same when these patients were divided into normocalciuric (n = 23), borderline… Expand
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