Corpus ID: 26616448

Metoclopramide : A Template for Drug Discovery

  title={Metoclopramide : A Template for Drug Discovery},
  author={G. Sanger},
  • G. Sanger
  • Published 2017
  • Metoclopramide was described in 1964 as an anti-emetic drug and stimulant of gastrointestinal motility. Dopamine D2 receptor antagonism explained the anti-emetic activity and was suggested to stimulate gastrointestinal motility. An important use of metoclopramide and other D2 receptor antagonists is to inhibit emesis caused by anticancer chemo radiotherapy. However, the use of new platinum-based anti-cancer drugs led to debilitating emesis, lasting for days and sometimes leading to refusal of… CONTINUE READING
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