Metnase Mediates Resistance to Topoisomerase II Inhibitors in Breast Cancer Cells

@article{Wray2009MetnaseMR,
  title={Metnase Mediates Resistance to Topoisomerase II Inhibitors in Breast Cancer Cells},
  author={Justin W Wray and Elizabeth A. Williamson and Melanie Royce and Montaser Shaheen and Brian D. Beck and Suk-hee Lee and Jac A. Nickoloff and Robert Hromas},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={565 - 569}
}
DNA replication produces tangled, or catenated, chromatids, that must be decatenated prior to mitosis or catastrophic genomic damage will occur. Topoisomerase IIalpha (Topo IIalpha) is the primary decatenating enzyme. Cells monitor catenation status and activate decatenation checkpoints when decatenation is incomplete, which occurs when Topo IIalpha is… CONTINUE READING