Meticulous prevention of hypoglycemia normalizes the glycemic thresholds and magnitude of most of neuroendocrine responses to, symptoms of, and cognitive function during hypoglycemia in intensively treated patients with short-term IDDM.

@article{Fanelli1993MeticulousPO,
  title={Meticulous prevention of hypoglycemia normalizes the glycemic thresholds and magnitude of most of neuroendocrine responses to, symptoms of, and cognitive function during hypoglycemia in intensively treated patients with short-term IDDM.},
  author={Carmine G. Fanelli and L. Epifano and A. M. Rambotti and Simone Pampanelli and Angelo Di Vincenzo and F T Modarelli and M J Lepore and Bruno Annibale and Marco Ciofetta and Paolo Bottini},
  journal={Diabetes},
  year={1993},
  volume={42 11},
  pages={1683-9}
}
To test the hypothesis that hypoglycemia unawareness is largely secondary to recurrent therapeutic hypoglycemia in IDDM, we assessed neuroendocrine and symptom responses and cognitive function in 8 patients with short-term IDDM (7 yr) and hypoglycemia unawareness. Patients were assessed during a stepped hypoglycemic clamp, before and after 2 wk and 3 mo of meticulous prevention of hypoglycemia, which resulted in a decreased frequency of hypoglycemia (0.49 +/- 0.05 to 0.045 +/- 0.03 episodes… CONTINUE READING
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