Methylxanthines and human health: epidemiological and experimental evidence.

@article{Beaudoin2011MethylxanthinesAH,
  title={Methylxanthines and human health: epidemiological and experimental evidence.},
  author={Marie-Soleil Beaudoin and Terry E. Graham},
  journal={Handbook of experimental pharmacology},
  year={2011},
  volume={200},
  pages={
          509-48
        }
}
When considering methylxanthines and human health, it must be recognized that in many countries most caffeine is consumed as coffee. This is further confounded by the fact that coffee contains many bioactive substances in addition to caffeine; it is rich in phenols (quinides, chlorogenic acid, and lactones) and also has diterpenes (fatty acid esters), potassium, niacin, magnesium, and the vitamin B(3) precursor trigonelline. There is a paradox as consumption of either caffeine or caffeinated… 
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References

SHOWING 1-10 OF 193 REFERENCES
The cardiovascular effects of methylxanthines.
TLDR
These findings do not exclude that the acute hemodynamic and neurohumoral effects of coffee consumption could have an adverse effect in selected patient groups who are more vulnerable for these effects, based on their genetic profile or medication use.
Coffee and Health: A Review of Recent Human Research
TLDR
Current available evidence suggests that it may be prudent for pregnant women to limit coffee consumption to 3 cups/d providing no more than 300 mg/d of caffeine to exclude any increased probability of spontaneous abortion or impaired fetal growth, and there is little evidence that coffee consumption increases the risk of cancer.
Coffee, glucose homeostasis, and insulin resistance: physiological mechanisms and mediators.
TLDR
It is evident that a better understanding of the role of coffee in the development and prevention of T2D has the potential to uncover novel therapeutic targets and nutraceutical formulations for the disease.
Effects of caffeine on human health
TLDR
It is concluded that for the healthy adult population, moderate daily caffeine intake is not associated with adverse effects such as general toxicity, cardiovascular effects, effects on bone status and calcium balance, changes in adult behaviour, increased incidence of cancer and effects on male fertility.
A chlorogenic acid-induced increase in GLP-1 production may mediate the impact of heavy coffee consumption on diabetes risk.
  • M. Mccarty
  • Biology, Medicine
    Medical hypotheses
  • 2005
TLDR
Dietary high in "lente carbohydrate", or administration of nutraceuticals/pharmaceuticals which slow the absorption of dietary carbohydrate, should help preserve efficient beta cell function by boosting GLP-1 production, as well as by blunting the glucotoxic impact of postprandial hyperglycemia on Beta cell function.
Caffeine impairs glucose metabolism in type 2 diabetes.
TLDR
This study tested how oral caffeine affects carbohydrate metabolism in patients with type 2 diabetes, for whom decreases in insulin sensitivity might result in exagger- ated hyperglycemic responses to glucose and other carbohydrates, which would aggravate the glycemic dysregulation found in the disease.
The glucose intolerance induced by caffeinated coffee ingestion is less pronounced than that due to alkaloid caffeine in men.
TLDR
It is suggested that the effects of CAF and RCOF are not identical and may provide a partial explanation as to why acute CAF ingestion impairs glucose tolerance while chronic R COF ingestion protects against type 2 diabetes.
Association of Caffeine Intake and CYP1A2 Genotype With Ovarian Cancer
TLDR
Preliminary data suggest a modest positive association of caffeine and coffee consumption with the OR for ovarian cancer that may be modified by CYP1A2 genotype and exposures, such as cruciferous vegetable consumption, that influence CYP 1A2 expression.
Effects of chronic coffee consumption on glucose kinetics in the conscious rat.
TLDR
Decaffeinated coffee may represent a nutritional means of combating insulin resistance and caffeine antagonizes the beneficial effects of DC, indicating increased whole-body insulin sensitivity.
Decaffeinated Coffee and Glucose Metabolism in Young Men
TLDR
Some types of decaffeinated coffee may acutely impair glucose metabolism but less than caffeine; however, caffeinated coffee acutely impairs glucose metabolism.
...
1
2
3
4
5
...