Corpus ID: 37293431

Methylxanthine induced cardiotoxicity and its mechanisms : An experimental study

@inproceedings{Shamsuzzaman2017MethylxanthineIC,
  title={Methylxanthine induced cardiotoxicity and its mechanisms : An experimental study},
  author={M. Shamsuzzaman and G. Kavita and Ray Arunabha},
  year={2017}
}
Background: Methylxanthines like theophylline are re-emerging as effective adjuncts in the treatment of obstructive airway disease and several newer mechanisms have been proposed. In view of its effectiveness, pharmacoeconomic viability, and easy availability, it could rationalize the drug treatment in bronchial asthma and chronic obstructive pulmonary disorders (COPD) – but its narrow therapeutic index and resultant safety concerns need to be aggressively addressed, particularly in developing… Expand
2 Citations

References

SHOWING 1-10 OF 33 REFERENCES
Possible role of free radicals in theophylline-induced seizures in mice
  • 32
Pharmacological studies on mechanisms of aminophylline-induced seizures in rats.
  • 23
  • PDF
A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression
  • K. Ito, Sam Lim, +4 authors P. Barnes
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2002
  • 467
  • PDF
Theophylline-induced seizures: clinical and pathophysiologic aspects.
  • 48
...
1
2
3
4
...