Methylxanthine drugs are chitinase inhibitors: investigation of inhibition and binding modes.

@article{Rao2005MethylxanthineDA,
  title={Methylxanthine drugs are chitinase inhibitors: investigation of inhibition and binding modes.},
  author={Francesco V. Rao and Ole Andreas Andersen and Kalpit A Vora and Julie A Demartino and Daan M F van Aalten},
  journal={Chemistry & biology},
  year={2005},
  volume={12 9},
  pages={973-80}
}
Family 18 chitinases play key roles in a range of pathogenic organisms and are overexpressed in the asthmatic lung. By screening a library of marketed drug molecules, we have identified methylxanthine derivatives as possible inhibitor leads. These derivatives, theophylline, caffeine, and pentoxifylline, are used therapeutically as antiinflammatory agents, with pleiotropic mechanisms of action. Here it is shown that they are also competitive inhibitors against a fungal family 18 chitinase, with… CONTINUE READING

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