Methyltransferase Recruitment and DNA Hypermethylation of Target Promoters by an Oncogenic Transcription Factor

@article{DiCroce2002MethyltransferaseRA,
  title={Methyltransferase Recruitment and DNA Hypermethylation of Target Promoters by an Oncogenic Transcription Factor},
  author={Luciano Di Croce and Veronica A. Raker and Massimo Corsaro and Francesco Fazi and Mirco Fanelli and Mario Faretta and François Fuks and Francesco Lo Coco and Tony Kouzarides and Clara Nervi and Saverio Minucci and Pier Giuseppe Pelicci},
  journal={Science},
  year={2002},
  volume={295},
  pages={1079 - 1082}
}
DNA methylation of tumor suppressor genes is a frequent mechanism of transcriptional silencing in cancer. The molecular mechanisms underlying the specificity of methylation are unknown. We report here that the leukemia-promoting PML-RAR fusion protein induces gene hypermethylation and silencing by recruiting DNA methyltransferases to target promoters and that hypermethylation contributes to its leukemogenic potential. Retinoic acid treatment induces promoter demethylation, gene reexpression… 
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