Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation.

  title={Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation.},
  author={F. Antignano and K. Burrows and M. Hughes and J. Han and K. Kron and N. Penrod and M. J. Oudhoff and S. Wang and P. H. Min and M. Gold and A. Chenery and M. Braam and Thomas C H Fung and F. Rossi and K. McNagny and C. Arrowsmith and M. Lupien and M. Levings and C. Zaph},
  journal={The Journal of clinical investigation},
  volume={124 5},
  • F. Antignano, K. Burrows, +16 authors C. Zaph
  • Published 2014
  • Medicine, Biology
  • The Journal of clinical investigation
  • Inflammatory bowel disease (IBD) pathogenesis is associated with dysregulated CD4⁺ Th cell responses, with intestinal homeostasis depending on the balance between IL-17-producing Th17 and Foxp3⁺ Tregs. Differentiation of naive T cells into Th17 and Treg subsets is associated with specific gene expression profiles; however, the contribution of epigenetic mechanisms to controlling Th17 and Treg differentiation remains unclear. Using a murine T cell transfer model of colitis, we found that T cell… CONTINUE READING
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