• Biology, Medicine
  • Published in
    The Journal of clinical…
    2014
  • DOI:10.1172/JCI69592

Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation.

@article{Antignano2014MethyltransferaseGR,
  title={Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation.},
  author={Frann Antignano and Kyle Burrows and Michael R Hughes and Jonathan M. Han and Ken J. Kron and Nadia M. Penrod and Menno J Oudhoff and S K Wang and Paul H Min and Matthew J. Gold and Alistair L Chenery and Mitchell Braam and Thomas C H Fung and Fabio M V Rossi and Kelly M McNagny and Cheryl H. Arrowsmith and Mathieu Lupien and Megan K Levings and Colby Zaph},
  journal={The Journal of clinical investigation},
  year={2014},
  volume={124 5},
  pages={
          1945-55
        }
}
Inflammatory bowel disease (IBD) pathogenesis is associated with dysregulated CD4⁺ Th cell responses, with intestinal homeostasis depending on the balance between IL-17-producing Th17 and Foxp3⁺ Tregs. Differentiation of naive T cells into Th17 and Treg subsets is associated with specific gene expression profiles; however, the contribution of epigenetic mechanisms to controlling Th17 and Treg differentiation remains unclear. Using a murine T cell transfer model of colitis, we found that T cell… CONTINUE READING

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