Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo.

@article{Congdon2012MethylthioniniumC,
  title={Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo.},
  author={Erin E. Congdon and Jessica W. Wu and Natura Myeku and Yvette H Figueroa and Mathieu Herman and Paul S Marinec and Jason E. Gestwicki and Chad A Dickey and Wai Haung Yu and Karen E Duff},
  journal={Autophagy},
  year={2012},
  volume={8 4},
  pages={609-22}
}
More than 30 neurodegenerative diseases including Alzheimer disease (AD), frontotemporal lobe dementia (FTD), and some forms of Parkinson disease (PD) are characterized by the accumulation of an aggregated form of the microtubule-binding protein tau in neurites and as intracellular lesions called neurofibrillary tangles. Diseases with abnormal tau as part of the pathology are collectively known as the tauopathies. Methylthioninium chloride, also known as methylene blue (MB), has been shown to… CONTINUE READING
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