Methylthioadenosine phosphorylase gene expression is impaired in human liver cirrhosis and hepatocarcinoma.

@article{Berasain2004MethylthioadenosinePG,
  title={Methylthioadenosine phosphorylase gene expression is impaired in human liver cirrhosis and hepatocarcinoma.},
  author={Carmen Berasain and Henar Hevia and Jokin Fern{\'a}ndez-Irigoyen and Esther Larrea and Juan Caballer{\'i}a and Jose M. Mato and Jes{\'u}s Prieto and Fernando Jos{\'e} Corrales and Elena Ruiz Garc{\'i}a-Trevijano and Mat{\'i}as A. Avila},
  journal={Biochimica et biophysica acta},
  year={2004},
  volume={1690 3},
  pages={276-84}
}
Methylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine and adenine salvage pathways. In mammals, the liver plays a central role in methionine metabolism, and this essential function is lost in the progression from liver cirrhosis to hepatocarcinoma. Deficient MTAP gene expression has been recognized in many transformed cell lines and tissues. In the present work, we have studied the expression of MTAP in human and experimental liver cirrhosis and hepatocarcinoma. We observe… CONTINUE READING