Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma.

@article{Sommer2010MethylthioadenosinePA,
  title={Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma.},
  author={Josh Sommer and Doha M Itani and Kelly C. Homlar and Vicki Leigh Keedy and Jennifer L. Halpern and Ginger E. Holt and Herbert S. Schwartz and Cheryl M. Coffin and Michael J. Kelley and Justin M M Cates},
  journal={The Journal of pathology},
  year={2010},
  volume={220 5},
  pages={
          608-17
        }
}
Currently there is no effective chemotherapy for chordoma. Recent studies report co-expression of insulin-like growth factor-1 receptor (IGF1R) and its cognate ligand in chordoma, but it is unknown whether this receptor tyrosine kinase is activated in these tumours. Additionally, genetic studies have confirmed frequent deletions of chromosome 9p in chordomas, which encompasses the cyclin-dependent kinase inhibitor 2A (CDKN2A) locus. Another gene in this region, methylthioadenosine phosphorylase… CONTINUE READING
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