Methyltetrahydrofolate Reductase C 677 T Mutation and 4 G / 5 G Plasminogen Activator Inhibitor-1 Polymorphism in a Child with Deep Vein Thrombosis

Introduction Methyltetrahydrofolate reductase (MTHFR) enzyme is responsible for conversion of 5, 10methyl tetrahydrofolate to 5-tetrahydrofolate for folic acid (folate) synthesis. One of the most common MTHFR mutations is a nucleotide transition from C-to-T at position 677 that results in amino acid alteration from alanine to valine. Coinheritance of MTHFR… CONTINUE READING

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