Methylsulfonylmethane modulates apoptosis of LPS/IFN-γ-activated RAW 264.7 macrophage-like cells by targeting p53, Bax, Bcl-2, cytochrome c and PARP proteins

@article{Karabay2014MethylsulfonylmethaneMA,
  title={Methylsulfonylmethane modulates apoptosis of LPS/IFN-γ-activated RAW 264.7 macrophage-like cells by targeting p53, Bax, Bcl-2, cytochrome c and PARP proteins},
  author={A. Karabay and F. Aktan and A. Sunguroǧlu and Z. Buyukbingol},
  journal={Immunopharmacology and Immunotoxicology},
  year={2014},
  volume={36},
  pages={379 - 389}
}
Abstract Methylsulfonylmethane (MSM) is a non-toxic, natural organosulfur compound, which is known to possess antioxidant and anti-inflammatory activities. In recent years, MSM has been widely used as a dietary supplement for its beneficial effects against various diseases, especially arthritis. Despite being a popular supplement product, the mechanism of action of MSM is not well known. This study was designed to investigate the effects of MSM on cytotoxic signals induced by lipopolysaccharide… Expand
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References

SHOWING 1-10 OF 62 REFERENCES
Bcl-2 Protects Macrophages from Nitric Oxide-induced Apoptosis*
  • 238
  • PDF
Nitric oxide synthase induces macrophage death by apoptosis.
  • 373
Nitric oxide-mediated apoptosis in murine peritoneal macrophages.
  • 867
...
1
2
3
4
5
...