Methylseleninic acid synergizes with tamoxifen to induce caspase-mediated apoptosis in breast cancer cells

@article{Li2008MethylseleninicAS,
  title={Methylseleninic acid synergizes with tamoxifen to induce caspase-mediated apoptosis in breast cancer cells},
  author={Zengshan Li and Latonya M Carrier and B. Rowan},
  journal={Molecular Cancer Therapeutics},
  year={2008},
  volume={7},
  pages={3056 - 3063}
}
Tamoxifen has efficacy as a breast cancer therapy and chemoprevention agent. However, toxicity and resistance to tamoxifen limit its clinical application. There is an urgent need to develop compounds that may be combined with tamoxifen to improve efficacy and overcome toxicity and resistance. We showed previously that the organoselenium compound methylseleninic acid (MSA) increased the growth-inhibitory effect of tamoxifen and reversed tamoxifen resistance in breast cancer cells. In this study… Expand
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