Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition.

@article{TarradoCastellarnau2015MethylseleninicAP,
  title={Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition.},
  author={M{\'i}riam Tarrado-Castellarnau and Rold{\'a}n Cort{\'e}s and M A Valero Zanuy and Josep Tarrag{\'o}-Celada and Ibrahim Halil Polat and Richard O. Hill and Teresa W-M Fan and Wolfgang Link and Marta Cascante},
  journal={Pharmacological research},
  year={2015},
  volume={102},
  pages={218-34}
}
Selenium supplement has been shown in clinical trials to reduce the risk of different cancers including lung carcinoma. Previous studies reported that the antiproliferative and pro-apoptotic activities of methylseleninic acid (MSA) in cancer cells could be mediated by inhibition of the PI3K pathway. A better understanding of the downstream cellular targets of MSA will provide information on its mechanism of action and will help to optimize its use in combination therapies with PI3K inhibitors… CONTINUE READING