Methylpurine DNA glycosylase of the hyperthermophilic archaeon Archaeoglobus fulgidus.

  title={Methylpurine DNA glycosylase of the hyperthermophilic archaeon Archaeoglobus fulgidus.},
  author={Nils-K{\aa}re Birkeland and Hilde Anensen and Ingeborg Knaevelsrud and Wenche Kristoffersen and Magnar Bj\or{\aa}s and Frank T Robb and Arne Klungland and Svein Bjelland},
  volume={41 42},
Base excision repair of DNA alkylation damage is initiated by a methylpurine DNA glycosylase (MPG) function. Such enzymes have previously been characterized from bacteria and eukarya, but not from archaea. We identified activity for the release of methylated bases from DNA in cell-free extracts of Archaeoglobus fulgidus, an archaeon growing optimally at 83 degrees C. An open reading frame homologous to the alkA gene of Escherichia coli was overexpressed and identified as a gene encoding an MPG… CONTINUE READING


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