Methylprednisolone treatments alter apomorphine-induced circling in the rat model of 6-hydroxydopamine-induced striatal denervation.

@article{Thomas1989MethylprednisoloneTA,
  title={Methylprednisolone treatments alter apomorphine-induced circling in the rat model of 6-hydroxydopamine-induced striatal denervation.},
  author={Jurgen Thomas and Vernice R. Jackson-Lewis and Stanley Fahn and Jean Lud Cadet},
  journal={The International journal of neuroscience},
  year={1989},
  volume={44 1-2},
  pages={149-54}
}
Intrastriatal injection of 6-hydroxydopamine causes significant depletion of dopamine which is associated with contralateral apomorphine-induced rotation in rats. Pretreatment with methylprednisolone (MP) causes almost complete elimination of the apomorphine-induced behavioral responses. In addition, there were significant differences between the… CONTINUE READING