Methylprednisolone treatment of patients with steroid-resistant nephrotic syndrome

  title={Methylprednisolone treatment of patients with steroid-resistant nephrotic syndrome},
  author={F. Bryson Waldo and Mark R. Benfield and Edward C. Kohaut},
  journal={Pediatric Nephrology},
Treatment with a combination of pulse methylprednisolone (MP) and an alkylating agent has been reported to induce long-term remission of proteinuria in patients with steroid-resistant nephrotic syndrome (SRNS). We have treated 13 patients with SRNS with a course of pulse MP. There were 8 black patients and 5 white; 10 had a biopsy diagnosis of focal segmental glomerulosclerosis (FSGS) and 3 nil lesion. Initially 5 patients responded and 2 partially responded. Of the responding patients, 5… CONTINUE READING


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