Methylprednisolone inhibits low-flow hypoxia-induced mitochondrial dysfunction in isolated perfused rat liver.

OBJECTIVE To investigate the mechanism by which methylprednisolone protects the liver from hypoxia-induced injury. DESIGN Prospective control study using the isolated rat liver. SETTING Animal research facility. SUBJECTS Male, fasted, pathogen-free Sprague-Dawley rats. INTERVENTIONS Low-flow hypoxia was produced by reducing afferent perfusate… CONTINUE READING