Methylprednisolone inhibits early inflammatory processes but not ischemic cell death after experimental spinal cord lesion in the rat.

@article{Bartholdi1995MethylprednisoloneIE,
  title={Methylprednisolone inhibits early inflammatory processes but not ischemic cell death after experimental spinal cord lesion in the rat.},
  author={Deborah Bartholdi and Martin E. Schwab},
  journal={Brain research},
  year={1995},
  volume={672 1-2},
  pages={177-86}
}
Experimental studies and clinical observations show that spinal cord lesions are greatly enlarged by a process called secondary cell death. A detailed understanding of the molecular and cellular processes underlying these events is still lacking. In clinical studies using methylprednisolone in spinal cord injured patients a mega-dose of methylprednisolone applied during the first few hours after injury was found to improve the neurological outcome. In the present study the possible… CONTINUE READING