Methylprednisolone causes minimal improvement after spinal cord injury in rats, contrasting with benefits of an anti-integrin treatment.

@article{Weaver2005MethylprednisoloneCM,
  title={Methylprednisolone causes minimal improvement after spinal cord injury in rats, contrasting with benefits of an anti-integrin treatment.},
  author={Lynne C. Weaver and Denis Gris and Leyana R Saville and Mark A Oatway and Yuhua Chen and Daniel R. Marsh and Eilis F Hamilton and Gregory A. Dekaban},
  journal={Journal of neurotrauma},
  year={2005},
  volume={22 12},
  pages={1375-87}
}
Spinal cord injury (SCI) leads to complex secondary events that expand and exacerbate the injury. Methylprednisolone (MP) has been considered a standard of care for acute SCI. The purpose of this study was to test the effects of MP, in severe and more moderate severe clip-compression models of SCI, on the measures of neurological function and lesion sparing that we used previously to assess a highly effective anti-inflammatory therapy, a monoclonal antibody (mAb) to the CD11d integrin… CONTINUE READING
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