Methylprednisolone Protects Cardiac Pumping Mechanics from Deteriorating in Lipopolysaccharide-Treated Rats

@inproceedings{Ko2015MethylprednisolonePC,
  title={Methylprednisolone Protects Cardiac Pumping Mechanics from Deteriorating in Lipopolysaccharide-Treated Rats},
  author={Ya-Hui Ko and Ming-Shian Tsai and Ru-Wen Chang and Chun-Yi Chang and Chih-Hsien Wang and M S Wu and J H Liang and K. C. Chang},
  booktitle={Front. Physiol.},
  year={2015}
}
It has been shown that a prolonged low-dose corticosteroid treatment attenuates the severity of inflammation and the intensity and duration of organ system failure. In the present study, we determined whether low-dose methylprednisolone (a synthetic glucocorticoid) can protect male Wistar rats against cardiac pumping defects caused by lipopolysaccharide-induced chronic inflammation. For the induction of chronic inflammation, a slow-release ALZET osmotic pump was subcutaneously implanted to… CONTINUE READING
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