Methylpiperate derivatives from Piper longum and their inhibition of monoamine oxidase

@article{Lee2008MethylpiperateDF,
  title={Methylpiperate derivatives from Piper longum and their inhibition of monoamine oxidase},
  author={Seon Ae Lee and Ji Sang Hwang and Xiang Hua Han and Chul Wee Lee and Min Hee Lee and Sanggil Choe and Seong Su Hong and Dongho Lee and Myung-Koo Lee and Bang Yeon Hwang},
  journal={Archives of Pharmacal Research},
  year={2008},
  volume={31},
  pages={679-683}
}
We have previously reported that piperine, a known piperidine alkaloid from Piper longum, competitively inhibited mouse brain MAO-A and MAO-B activities. Piperine also showed in vivo antidepressant-like activity against the tail suspension test. In the present study, we further expanded on the identification of MAO inhibitors from the fruit of P. longum. Activity-guided fractionation of a methylene chloride soluble extract led to the isolation of three known piperine-related compounds… 
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Piperine (1 - piperoyl piperidine) is the major alkaloid responsible for the pungent smell of the West African pepper, Piper guineense, a plant whose parts are well known for their traditional…
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