• DOI:10.1007/s12272-001-1212-7
Corpus ID: 45675434

Methylpiperate derivatives from Piper longum and their inhibition of monoamine oxidase

@article{Lee2008MethylpiperateDF,
  title={Methylpiperate derivatives from Piper longum and their inhibition of monoamine oxidase},
  author={S. A. Lee and J. S. Hwang and X. Han and C. Lee and M. H. Lee and Sang Gil Choe and S. Hong and Dongho Lee and M. K. Lee and B. Hwang},
  journal={Archives of Pharmacal Research},
  year={2008},
  volume={31},
  pages={679-683}
}

S. A. Lee, J. S. Hwang, +7 authors B. Hwang

Published 2008

Chemistry, Medicine

Archives of Pharmacal Research

We have previously reported that piperine, a known piperidine alkaloid from Piper longum, competitively inhibited mouse brain MAO-A and MAO-B activities. Piperine also showed in vivo antidepressant-like activity against the tail suspension test. In the present study, we further expanded on the identification of MAO inhibitors from the fruit of P. longum. Activity-guided fractionation of a methylene chloride soluble extract led to the isolation of three known piperine-related compounds… CONTINUE READING

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