Methylpiperate derivatives from Piper longum and their inhibition of monoamine oxidase

@article{Lee2008MethylpiperateDF,
  title={Methylpiperate derivatives from Piper longum and their inhibition of monoamine oxidase},
  author={S. A. Lee and J. S. Hwang and X. Han and C. Lee and M. H. Lee and Sang Gil Choe and S. Hong and Dongho Lee and M. K. Lee and B. Hwang},
  journal={Archives of Pharmacal Research},
  year={2008},
  volume={31},
  pages={679-683}
}
  • S. A. Lee, J. S. Hwang, +7 authors B. Hwang
  • Published 2008
  • Chemistry, Medicine
  • Archives of Pharmacal Research
  • We have previously reported that piperine, a known piperidine alkaloid from Piper longum, competitively inhibited mouse brain MAO-A and MAO-B activities. Piperine also showed in vivo antidepressant-like activity against the tail suspension test. In the present study, we further expanded on the identification of MAO inhibitors from the fruit of P. longum. Activity-guided fractionation of a methylene chloride soluble extract led to the isolation of three known piperine-related compounds… CONTINUE READING
    38 Citations
    Synthesis and inhibitory effect of piperine derivates on monoamine oxidase.
    • 27
    New amide alkaloids from Piper longum fruits
    • 9
    • PDF
    New Amides and Phenylpropanoid Glucosides from the Fruits of Piper retrofractum
    • 2
    • PDF

    References

    SHOWING 1-10 OF 26 REFERENCES
    Piperine from the fruits of Piper longum with inhibitory effect on monoamine oxidase and antidepressant-like activity.
    • 153
    • PDF
    A review of the mechanisms and role of monoamine oxidase inhibitors in Parkinson’s disease
    • 67
    Immunomodulatory and antitumor activity of Piper longum Linn. and piperine.
    • 389
    Monoamine oxidase-B inhibitors in the treatment of Alzheimers disease
    • 155
    • PDF
    Monoamine oxidase: from genes to behavior.
    • 964
    • Highly Influential
    • PDF
    Clinical pharmacology of MAO inhibitors: safety and future.
    • 256
    Guineensine, an Acyl-CoA: cholesterol acyltransferase inhibitor, from the fruits of Piper longum.
    • 14
    Evaluation of the liver protective potential of piperine, an active principle of black and long peppers.
    • 157
    Molecular characterization of monoamine oxidases A and B.
    • C. Abell, S. Kwan
    • Biology, Medicine
    • Progress in nucleic acid research and molecular biology
    • 2001
    • 99