Methylpiperate derivatives from Piper longum and their inhibition of monoamine oxidase
@article{Lee2008MethylpiperateDF, title={Methylpiperate derivatives from Piper longum and their inhibition of monoamine oxidase}, author={S. A. Lee and J. S. Hwang and X. Han and C. Lee and M. H. Lee and Sang Gil Choe and S. Hong and Dongho Lee and M. K. Lee and B. Hwang}, journal={Archives of Pharmacal Research}, year={2008}, volume={31}, pages={679-683} }
We have previously reported that piperine, a known piperidine alkaloid from Piper longum, competitively inhibited mouse brain MAO-A and MAO-B activities. Piperine also showed in vivo antidepressant-like activity against the tail suspension test. In the present study, we further expanded on the identification of MAO inhibitors from the fruit of P. longum. Activity-guided fractionation of a methylene chloride soluble extract led to the isolation of three known piperine-related compounds… CONTINUE READING
38 Citations
Synthesis and inhibitory effect of piperine derivates on monoamine oxidase.
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 2012
- 27
Inhibition of monoamine oxidase by derivatives of piperine, an alkaloid from the pepper plant Piper nigrum, for possible use in Parkinson's disease.
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 2012
- 29
Potent selective monoamine oxidase B inhibition by maackiain, a pterocarpan from the roots of Sophora flavescens.
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 2016
- 34
Alkaloids as Inhibitors of Monoamine Oxidases and Their Role in the Central Nervous System
- Biology
- 2014
- 5
Natural based piperine derivatives as potent monoamine oxidase inhibitors: an in silico ADMET analysis and molecular docking studies
- Chemistry, Medicine
- BMC Chemistry
- 2020
- 3
- PDF
Selective MAO-B inhibitors: a lesson from natural products
- Chemistry, Medicine
- Molecular Diversity
- 2013
- 74
New Amides and Phenylpropanoid Glucosides from the Fruits of Piper retrofractum
- Chemistry, Medicine
- Natural Products and Bioprospecting
- 2019
- 2
- PDF
References
SHOWING 1-10 OF 26 REFERENCES
Piperine from the fruits of Piper longum with inhibitory effect on monoamine oxidase and antidepressant-like activity.
- Chemistry, Medicine
- Chemical & pharmaceutical bulletin
- 2005
- 153
- PDF
A review of the mechanisms and role of monoamine oxidase inhibitors in Parkinson’s disease
- Medicine
- Neurology
- 2004
- 67
Immunomodulatory and antitumor activity of Piper longum Linn. and piperine.
- Medicine, Biology
- Journal of ethnopharmacology
- 2004
- 389
Monoamine oxidase-B inhibitors in the treatment of Alzheimers disease
- Medicine
- Neurobiology of Aging
- 2000
- 155
- PDF
Monoamine oxidase: from genes to behavior.
- Chemistry, Medicine
- Annual review of neuroscience
- 1999
- 964
- Highly Influential
- PDF
Piperlonguminine from Piper longum with inhibitory effects on alpha-melanocyte-stimulating hormone-induced melanogenesis in melanoma B16 cells.
- Biology, Medicine
- Planta medica
- 2004
- 16
Guineensine, an Acyl-CoA: cholesterol acyltransferase inhibitor, from the fruits of Piper longum.
- Biology, Medicine
- Planta medica
- 2004
- 14
Evaluation of the liver protective potential of piperine, an active principle of black and long peppers.
- Chemistry, Medicine
- Planta medica
- 1993
- 157
Molecular characterization of monoamine oxidases A and B.
- Biology, Medicine
- Progress in nucleic acid research and molecular biology
- 2001
- 99