Methylphenidate sensitization is prevented by prefrontal cortex lesion.

@article{Lee2008MethylphenidateSI,
  title={Methylphenidate sensitization is prevented by prefrontal cortex lesion.},
  author={Min Jung Lee and Alan C. Swann and Nachum Dafny},
  journal={Brain research bulletin},
  year={2008},
  volume={76 1-2},
  pages={131-40}
}
Methylphenidate (MPD), also known as Ritalin, is a widely used treatment for Attention Deficit Hyperactivity Disorder. Repeated administration of MPD causes dose-dependent sensitization. MPD binds to dopamine (DA) transporters, and DA, therefore, remain in the synaptic cleft for longer time, resulting in an indirect DA agonist effect. MPD affects neurotransmission in brain regions including the prefrontal cortex (PFC). The mechanisms of sensitization to MPD are not clear. The aim of this study… CONTINUE READING

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