Methylphenidate is likely less effective than placebo for improving imbalance, walking, and fatigue in people with multiple sclerosis.

@article{Cameron2017MethylphenidateIL,
  title={Methylphenidate is likely less effective than placebo for improving imbalance, walking, and fatigue in people with multiple sclerosis.},
  author={Michelle H. Cameron and Garnett McMillan},
  journal={Multiple sclerosis},
  year={2017},
  volume={23 13},
  pages={
          1799-1801
        }
}
Methylphenidate, an amphetamine-like psychomotor stimulant, alleviates fatigue in many patient populations and is recommended, and often prescribed offlabel, to improve fatigue in multiple sclerosis (MS).1 Recent research also supports that methylphenidate can improve balance and walking in various populations,2–4 but no published studies have evaluated the effects of repeated doses of methylphenidate on fatigue, balance, or walking in MS. 
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