Methylphenidate hydrochloride given with or before breakfast: II. Effects on plasma concentration of methylphenidate and ritalinic acid.

  title={Methylphenidate hydrochloride given with or before breakfast: II. Effects on plasma concentration of methylphenidate and ritalinic acid.},
  author={You Ping Chan and James M. Swanson and S. S. Soldin and Jake J. Thiessen and Stuart M. Macleod and William J. Logan},
  volume={72 1},
Methylphenidate HCl (Ritalin) is often prescribed for the treatment of hyperactivity and is usually administered orally 30 minutes to 1 hour before meals, based on an assumption that meals may interfere with the absorption or metabolism of the drug. Seven boys who were taking methylphenidate regularly for the treatment of hyperactivity were hospitalized and given their established dose of the drug intravenously or orally, either with breakfast or in a fasted state. Blood samples were taken to… 
Pharmacokinetics and therapeutic effect of OROS methylphenidate under different breakfast conditions in children with attention-deficit/hyperactivity disorder.
It is demonstrated that in children with attention-deficit/hyperactivity disorder, administering OROS MPH with or without food produces similar PK and PD profiles, as demonstrated by the Swanson, Kotkin, Agler, M-Flynn, and Pelham Attention and Deportment measures and global assessments.
Pharmacokinetics and Clinical Effectiveness of Methylphenidate
It is difficult to predict which children will have a favourable response to methylphenidate, and therefore dosage must be titrated for optimal effect and avoidance of toxicity in each child, and further studies of the relationship between the pharmacokinetic and pharmacodynamic properties are required to allow the development of optimal dosage regimens.
Effects of Food on the Pharmacokinetics of Methylphenidate
Testing the hypothesis that the pharmacokinetics of d-meth- ylphenidate (d-MPH) would be altered by food ingested before administration of an immediate release formulation but not when food is ingested before a slow release formulation found no effect on rate of absorption.
Bioavailability of modified‐release methylphenidate: influence of high‐fat breakfast when administered intact and when capsule content sprinkled on applesauce
The pharmacokinetics of modified‐release methylphenidate (highest single dose), Ritalin® LA, when administered under fasting condition, with a high‐fat breakfast, and when sprinkled on applesauce in healthy adult subjects were evaluated and the dose was safe and generally well tolerated.
Pharmacology of methylphenidate, amphetamine enantiomers and pemoline in attention‐deficit hyperactivity disorder
Methylphenidate appears to produce psychostimulation by inhibiting the presynaptic uptake of impulse‐released dopamine, and pemoline appears to both release and block the uptake of dopamine.
Methylphenidate blood levels and therapeutic response in children with attention-deficit hyperactivity disorder: I. Effects of different dosing regimens.
The rate of absorption and elimination of d- MPH was dependent on the pattern of administration, particularly on the initial bolus concentration, which suggests that d-MPH may act on the gastrointestinal system to slow absorption of additional d-MKH.
Effect of food on the pharmacokinetics of osmotic controlled‐release methylphenidate HCl in healthy subjects
The results indicate the absence of dose dumping from OROS® (methylphenidate HCl) in the presence of food, and food does not impede drug absorption and OROS ( methylphenidate) may be administered in the fed or fasted state.
Methylphenidate Controlled-Delivery Capsules (Equasym™XL, Metadate CD™)
Methylphenidate CD resulted in superior control of ADHD symptoms compared with osmotic release oral system (OROS®) methylphenidate over a time period corresponding to that of an average school day in a laboratory classroom, in 3-week clinical trials conducted in a community setting.
Pharmacokinetics of Methylphenidate After Oral Administration of Two Modified-Release Formulations in Healthy Adults
Results indicate that the recommended starting dose of the Ritalin® LA 20mg capsule formulation provides more rapid absorption and higher peak plasma concentrations than the recommended 18mg starting doses of the Concerta® formulation.
Methylphenidate and its Isomers
It is concluded that d-threo-methylphenidate, which is the more potent and abundant of the two isomers, is the major contributor of both efficacy and adverse effects, irrespective of the formulation or route of administration of the racemate.


Methylphenidate hydrochloride given with or before breakfast: I. Behavioral, cognitive, and electrophysiologic effects.
Eleven patients with attention deficit disorder were tested to evaluate this hypothesis using a double-blind crossover design (methylphenidate with or before breakfast) with a placebo control condition, and none of the measurements showed a significant difference between the conditions when methylphenidate was given with breakfast.
Clinical studies of methylphenidate serum levels in children and adults.
Progress is reported on the progress in applying a reliable and sensitive gas chromatography-mass spectrometric assay for MPH in serum to clinical studies of hyperactive children and adults.
Methylphenidate: A Review
Methylphenidate is a useful, proven method for the effective treatment of minimal brain dysfunction (MBD). Dosage should be titrated individually for each patient, and it is best to start with small
Psychopharmacology of attention deficit disorder: pharmacokinetic, neuroendocrine, and behavioral measures following acute and chronic treatment with methylphenidate.
The concentration of MPH in single "spot" samples obtained at two to three hours after administration of medication were significantly correlated with the percentage of improvement in the abbreviated Conners rating scale, indicating a relationship between plasma MPH concentration and clinical response.
A liquid-chromatographic analysis for ritalinic acid [alpha-phenyl-alpha-(2-piperidyl) acetic acid] in serum.
A "high-performance" liquid-chromatographic assay for measuring ritalinic acid in 300 muL of serum that affords good day-to-day precision (CV, less than 12%) and allows for the reliable analysis at concentrations greater than 50 microgram/L.
Children’s Learning and Attention Problems
Only for you today! Discover your favourite childrens learning and attention problems book right here by downloading and getting the soft file of the book. This is not your time to traditionally go
On the treatment of narcolepsy.