Methylphenidate for the treatment of apathy in Alzheimer disease: prediction of response using dextroamphetamine challenge.

@article{Herrmann2008MethylphenidateFT,
  title={Methylphenidate for the treatment of apathy in Alzheimer disease: prediction of response using dextroamphetamine challenge.},
  author={Nathan Herrmann and Lana S Rothenburg and Sandra E. Black and Michelle Ryan and Barbara A. Liu and Usoa E. Busto and Krista L. Lanct{\^o}t},
  journal={Journal of clinical psychopharmacology},
  year={2008},
  volume={28 3},
  pages={296-301}
}
Apathy is a common behavioral symptom of Alzheimer's disease (AD), being present in up to 70% of patients. Apathy in AD and non-AD populations has been associated with dysfunction in the dopaminergic brain reward system, suggesting that pharmacotherapeutic targeting of this system may be an effective treatment for apathy in AD. We therefore performed a randomized, double-blind, placebo-controlled crossover trial of methylphenidate in a sample of 13 apathetic AD patients (6 men, 7 women; age… CONTINUE READING
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