Methylphenidate enhances noradrenergic transmission and suppresses mid- and long-latency sensory responses in the primary somatosensory cortex of awake rats.


Noradrenergic neurons send widespread projections to sensory networks throughout the brain and regulate sensory processing via norepinephrine (NE) release. As a catecholamine reuptake blocker, methylphenidate (MPH) is likely to interact with noradrenergic transmission and NE modulatory action on sensory systems. To characterize the neurochemical actions of… (More)

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