Methylphenidate enhances inhibitory synaptic transmission by increasing the content of norepinephrine in the locus coeruleus of juvenile rats.

@article{Kidani2010MethylphenidateEI,
  title={Methylphenidate enhances inhibitory synaptic transmission by increasing the content of norepinephrine in the locus coeruleus of juvenile rats.},
  author={Yuri Kidani and Masaru Ishimatsu and Takashi Akasu},
  journal={The Kurume medical journal},
  year={2010},
  volume={57 1-2},
  pages={29-38}
}
The present study examined the effect of methylphenidate (MPH), a psychostimulant, on nor-adrenergic transmission in the locus coeruleus (LC) of juvenile rats. Intracellular recordings showed that MPH (>3 µM) produced a hyperpolarizing response associated with a decrease in the rate of spontaneously firing action potentials. MPH (1 µM) enhanced the amplitude of the inhibitory postsynaptic potential (IPSP) mediated by norepinephrine (NE), but did not change the excitatory postsynaptic potential… CONTINUE READING
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